Diclofenac sodium or Voltaren is a nonsteroidal antiinflammatory drug (NSAID) widely used for treatment of a variety of disorders, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle pain., hepatic injury is one of the health hazards resulting from oxidative damage. The main objective of the present study was to find if Moringa oleifera a novel hepatoprotective can amolerate histological and biochemical changes evoked by both acute effects of large doses of DIC(50,100,150mg/kg ) or chronic use of therapeutic dose 8 mg /kg . 9 groups of animals each group 10 rats were used in this study :control group I,G2I :8mg/kg, G2IIa:50mg/kg, G 2II b:100mg/kg, G 2II c: 150mg/kg, G3I: 8mg/kg+MO, G3IIa: 50mg/kg+MO, G3II b:100mg/kg+MO , G3II c:150mg/kg+MO. Biochemical studies showed significant alteration in liver function tests as increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST)and alkaline phosphatase(ALP) which are dose and duration dependant .Light microscopic changes in the form of sinusoidal dilation and congestion, bile duct proliferation . mild lymphocyte infiltration were observed and were dose and duration dependant. ultra structure changes showed cytoplasmic regions of degenerated organelles appeared as irregular moderate electron dense masses with lucent centers , some mitochondrial alteration ,prominent Vonkupffer cells and lipid droplets within ito cells. Conclusion administration with water Moringa oleifera extract before DIC treatment significantly ameliorated the indices of hepatotoxicity induced by DIC. these results suggest that MO inhibit DIC induced hepatotoxicity .